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Karen

Beckwith-Wiedemann syndrome

IVF

genome

epigenetic

dot

And, I do feel frustrated that Karen might possibly have Beckwith-Wiedemann syndrome as the, because we had IVF. But at the time, it was the right decision to make.
And I think that we should look again at the IVF procedures, the conditions that are being used and carry out better and more precise experiments to see how we can avoid throwing these epigenetic switches.
Wolf had shown a simple change in environment was enough to turn a gene on or off. But there was more. Everyone thought that any altered switches could not be inherited. He took some mice with altered gene switches and bred them.
Our expectation was that as the altered genome was passed to the children that any epigenetic changes would be wiped clean.
When he looked at the gene profile of the offspring, he was amazed.
You have dots that you were looking at, and every dot means a gene is on. And all of a sudden, you know, somebody said, "Wow, look at that."
The epigenetic switch thrown in one generation was clearly also present in the second generation.

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