1. I'll give it my best shot. 我会尽力的。
Hey, don't worry, I'll give it my best shot.

2. You gotta give him hell. 你得给他颜色看看。

3. give me a hand 帮我一下
Hey, can you give me a hand?

4. What gives? 最近怎样?
Hey, what's up? What gives, man?

5. I don't give a damn. 我不在乎。
OK, I don't give a damn. Or I don't give a crap.