听写填空,只写填空内容,不抄全文,5-10句,不用写标号,注意标点,口语中因结巴等问题造成的重复单词只写一遍~

Hint:
sirtuins

Lenny Guarente, a biology professor at MIT, is trying to learn how to manipulate the genes that could extend human life.

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Lenny Guarente: [---7---] Being more realistic, drugs are not perfect. [---8---]

You're been listening to Lenny Guarente. And I'm Lindsay Patterson from E&S, a clear voice for science.

【视听版科学小组荣誉出品】
One guide would be to look at what happens in the laboratory when you take a mouse and restrict the calories and give it this diet that has adequate nutrition but low calories. Guarente said a low-calorie diet, below 1,500 calories daily, triggers anti-aging genes called sirtuins. That can extend their life span by something like 1/3. He said there's an evolutionary reason for this. The thing is when conditions become harsh, and food is less available, then what these sirtuin genes do is they shift the strategy towards maintenance, and that's the state that would promote longevity and disease resistance. Guarente said a drug might be developed to give the same effect as a low-calorie diet. If things work the same in people as in mice, and if you had a perfect drug, you might imagine that you could extend life span by something like 20, 30 years. I think maybe we can get ten years of healthier living, and possibly longer living.