有什么问题吗的英语表达可以是：What is your problem？或者用疑问语气的Any problem？就可以表达。表示对他人的问候时可以说：What's the matter with you?
What is your problem? I'm your boss.
What is your problem anyway?
You know? I'm focused! What is your problem?
What is your problem with him anyways?
Then what is your problem?
Will that bother you? What is your problem with footballers?
What is your problem in studying English?
You are acting strangely. What's the matter with you?
What's the matter with you? You haven't done enough hero work for one day?
What's the matter with you? Are you looking to get run over?
He's coming back this morning. what's the matter with you?
What's the matter with you, walking along with a long face?