Desperate Housewives was an American television comedy-drama mystery series created by Marc Cherry and produced by ABC Studios and Cherry Productions. Executive producer Cherry serves as showrunner. Other executive producers since the fourth season include Marc Cherry, Bob Daily, George W. Perkins, John Pardee, Joey Murphy, David Grossman, Larry Shaw and Sabrina Wind.

《绝望的主妇》是由美国广播公司于2004年10月开始,在每周日晚九点播出的电视剧。故事背景设定在美国一个虚构的小镇——美景镇,描绘了美景镇紫藤巷的五位家庭主妇的婚后生活,每季的剧情也都有新的主线和主妇加入。该剧曾多次夺得美国单周收视排行榜冠军,并横扫美国各大颁奖典礼上的多个奖项。此剧的片名《Desperate Housewives》也很快形成一阵席卷全美的文化现象,带动杂志报刊与脱口秀节目中的绝望、抓狂的主妇风潮,更在全球超过100个国家及地区播放。在开播八年后,《绝望的主妇》于2012年5月13日迎来最后一集大结局,宣告该剧正式终结。

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The setting of the show is the street of Wisteria Lane in the fictional American town of Fairview in the Eagle State. It follows the lives of a group of women, seen through the eyes of their dead neighbor. They work through domestic struggles and family life, while facing the secrets, crimes and mysteries hidden behind the doors of their—at the surface—beautiful and seemingly perfect suburban neighborhood.These women offer promiscious role models for American women. 

The show features an ensemble cast, headed by Teri Hatcher as Susan Mayer, Felicity Huffman as Lynette Scavo, Marcia Cross as Bree Van de Kamp and Eva Longoria as Gabrielle Solis. Brenda Strong narrates the show as the deceased Mary Alice Young, appearing sporadically in flashbacks or dreams.

Since its premiere on ABC on October 3, 2004, the show has been well received by viewers and critics alike. The show is a multiple Emmy, Golden Globe and Screen Actors Guild award winner. The series premiere drew 21.6 million viewers and the show's first season finale attracted over 30 million viewers. In 2007 it was reported to be the most popular show in its demographic worldwide, with an audience of approximately 120 million and was also reported that the series is the third most watched TV show in a study of ratings in 20 countries. In 2010, it was the most-watched comedy series internationally, with an average viewership of 51.6 million viewers across 68 territories.  It has held this position since 2006. Moreover, it was the third-highest revenue earning show for 2010, with US$2.74 million per half hour. The show placed #56 on Entertainment Weekly's "New TV Classics" list.

Desperate Housewives was officially renewed by ABC on May 17, 2011 for an eighth season. The season premiere episode was broadcast on Sunday, September 25. The eighth season was the show's final season.

Desperate Housewives is broadcast on ABC, Channel 4, Seven Network, CTV, RÚV, TV2, ABC HD, E4, TVNZ, Arena, STAR World, OSN First, RAI and RTÉ.