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这是一篇涉及“物质滥用”的文章。

aspirin

We live a society in which the medicinal and social use of substances (drugs) is pervasive: an aspirin to quiet a headache, some wine to be sociable, coffee to get going in the morning, a cigarette for the nerves. When do these socially acceptable and apparently constructive uses of a substance become misuses? First of all, most substances taken in excess will produce negative effects such as poisoning or intense perceptual distortions. Repeated use of a substance can also lead to physical addiction or substance dependence. Dependence is marked first by an increased tolerance, with more and more of the substance required to produce the desired effect, and then by the appearance of unpleasant withdrawal symptoms when the substance is discontinued.
我们生活在一个物质（药物）在医疗和社交方面使用广泛的社会里：用来缓解头痛的阿斯匹林，用来应酬的酒，早晨用来提神的咖啡，还有定神用的香烟。这些物质的使用得到了社会认可，且显然具有积极的作用，但什么时候就变成滥用了呢？首先，大多数物质的过量使用都会产生负面影响，如中毒或严重的知觉错乱。反复使用一种物质可以导致成瘾或对该物质的依赖。依赖的最初表现是不断增长的耐药量，要产生预期的效果需要的药剂量越来越大，然后是一旦中断使用就会出现难受的停药症状。